International Journal of Epidemiology 39:56-162
The effect of rotavirus vaccine on diarrhoea mortality
Quote:
Background
<snip>
Results
We identified six papers for abstraction, reporting results from four studies.
No studies reported diarrhoea or rotavirus deaths, but all studies showed
reductions in hospitalizations due to rotavirus or diarrhoea of any aetiology,
severe and any rotavirus infections and diarrhoea episodes of any aetiology
in children who received rotavirus vaccine compared with placebo.
Effectiveness against very severe rotavirus infection best approximated
effectiveness against the fraction of diarrhoea deaths attributable to rotavirus,
and was estimated to be 74% (95% confidence interval: 35–90%).
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Again, I know of few things in life that is perfect.
I suspect answers to all of your questions are available, and they
overwhelmingly support the safety and efficacy of CDC-recommended
vaccines in use today.
OTOH while death is an easy endpoint to measure,
it is certainly not the be-all, end-all justification for public health.
There are always trade-offs to be made, sometimes they are
balanced to achieve the most good for the most people.