YMMV. But if I had a comic I wanted to run online, I'd use one of the many sites out there that are devoted to this. (Keenspot leaps to mind immediately, but I know there are others.)
The infrastructure you'll need is already there--things like archives, next comic, previous comic, etc. And the audience you'll need is already there. Of course they're coming for other comics, not yours, but in my book it would be better than starting with a completely separate site.
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