You're crazy or foolish.
It could work, if the increase in productivity offset the cost. The store would be one way, except if people come in when you're on a roll, or up against a deadline. If it was busy enough you could hire somebody to handle the store sales and be your office manager too.
Owning the building means maintenance, taxes, insurance, utilities, and incidental costs. A brick and mortar business, even without the store, means business permits and taxes... and you lose the home office tax deduction.
You could also hole up in the second floor, and rent out the first floor to someone to run their own business.
But Merc says, when Obama gets elected he's going to drive all the small businesses into the poor house.