The best answer I've found is to keep several of those "cans of air" around, and every year or so, take the whole computer OUTSIDE, open the case, and blow everything out.
It takes several cans because after about 20-30 seconds the can freezes and loses its power. But you don't want all that dust to blow around indoors.
I worked for a supermarket chain and we would do that. You wouldn't believe the amount of dust and gunk that anything in a supermarket accumulates. The cloud it would produce was impressive!
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