I run Gentoo on a server I built 2 years ago - easy to keep up to date, and very powerful; also very easy to install programs. Some might say a downside is all programs are built from source. Recently a livecd has been created (last year?), and more recently a GUI installer.
But if you want something you can just install and go with, Kubuntu. Or you can get a modified version of Mac OS that'll run on Intel/AMD hardware.
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