This year you aren't rich enough, next year they'll be under $100.
I've never seen data on whether drives prefer to run all the time or be power-cycled on for occasional use. The manufacturers claim to rate them with a Mean Time Between Failure number, and it's in hours; so you'd figure, if you're going to use them for an hour, and then not use them for 23, best to shut off. But the manufacturers do capture the number of times a drive is powered on in the S.M.A.R.T. data kept on all modern drives, so they consider that meaningful.
All that said - in an external enclosure heat is more likely to be a problem. So my vote is, power it off.
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