Many years ago I recall seeing a guitar player who was sponsored by Ibanez. One day he had a new guitar. Instead of plugging in one of those quarter-inch plugs, he had a cable with an RS-232 connector on it. The other end patched through the high-tech keyboardy thing (honestly don't recall the brand, was either an Ensonics or a Korg) and did all kinds of amazing MIDI things with it.
This was in 1987 or so.
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