Oh, there are so many ...
From the "April Fool's" Episode:
In the flashback, where the origin of April Fool's is discussed, and the early Christian Flanders come to visit the late Pagan Simpsons ... "Heidiliho Pagans! We've come to bring you some ram's blood for your godless ceremonies."
Then, of course, there is the moment of insight in "Homer Gets Fat" where Homer and Bart go to visit Dr Nick (who, incidentally, sounds exactly like an Emergency Room Physician I deal with) and he's explaining to Homer the rationale behind choosing foods that will help him meet his goal of going on disability for being fat ... "And remember, if you're not sure about something, rub it against a piece of paper.
If the paper turns clear, it's your window to weight gain"
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