Y'know all this stuff gets much worse on guitar, where not only is every string tuned, it's intonated, sometimes to the right length; and every fret is layed down semi-permanently; and the whole thing responds to moisture and heat and etc; and the tuners are often cheap and don't hold a tuning well.
So sometimes - maybe a lot of times, if you have a good ear - you'll come across a guitar and play one chord, and it sounds just awesome; and then play another chord, and it sounds like total crap.
As for me, I'm playing fretless bass on one song right now for an audition next week, so I won't have ANY of those tuning problems ----
---- I know for absolute certain that no note I play will be in tune with anything else.